Non-Replicating Protein Nanoparticle-based Rotavirus Vaccine

A non-replicating nanoparticle-based rotavirus varrine is being developed by InThera, in collaboration with Sungshin Women’s University, to prevent severe gastroenteritis in infants and toddlers. The new vaccine approach of this project utilizes an encapsuling VLP (virus-like particle) and a trivalent subunit protein of the human rotavirus. The scope of work includes physiochemical characterization, trivalent formulation, pre-clinical pharmacology, and toxicology studies. This project addresses the need for non-replicating parenteral rotavirus vaccine candidates to overcome the lower efficacy and effectiveness of conventional oral rotavirus vaccines in LMICs.